NORC - Centers

Washington University

DIRECTOR Samuel Klein, MD - Washington University NORC Website


The Washington University Nutrition Obesity Research Center (NORC) activities enhance our understanding of the basic and clinical aspects of nutrition in the prevention, etiology, pathophysiology and therapy of nutrition-related diseases. Since its inception in 1999, the NORC has served as a nucleus for the growth and development of nutrition and obesity research at Washington University. The NORC hasĀ four core facilities including: Adipocyte Biology Molecular Nutrition Core (ABMN), Animal Model Research Core (AMR), Biomolecular Analysis Core (BMA), and Clinical Science Research Core (CSR).

The NORC is focused around three major interactive Program Themes:
  • Obesity: Pathophysiology, Complications and Therapeutics
  • Nutrient Metabolism in Health and Disease
  • Growth, Development, and Aging
The overall goals of the NORC are to support these themes by:
  • Stimulating innovative, interdisciplinary research and attract new and established investigators to the field of nutrition and obesity by providing state-of-the-art, cost effective Core Research Laboratory services, exposure to leading edge research, critical feedback on ongoing research at our research conferences, access to specialized training, and support from our Pilot and Feasibility Program
  • Improving the training and education of students, house-staff, postdoctoral fellows, faculty, and allied health personnel in clinical nutrition/obesity and in nutrition/obesity research
  • Supporting and enhancing clinical nutrition and weight management services
  • Stimulating and promoting community outreach activities in nutrition and obesity in the greater St. Louis Metropolitan area


Adipocyte Biology and Molecular Nutrition (ABMN)
The ABMN Core provides support for the study of adipose tissue biology and of the molecular basis of nutritional effects on metabolism in health and disease.

Animal Model Research (AMR)
The Animal Model Research Core provides breeding and colony maintenance of rodent models used for nutrition-related research (e.g. animals with lipid abnormalities, atherosclerosis, obesity and diabetes), genotyping, histological analyses, biochemical measurements (plasma lipids, glucose, and hormones) and body composition analysis.

Biomolecular Analysis (BMA)
The Biomolecular Analysis Core provides service, collaboration, training and advice on mass spectrometry-based analysis of biomolecules involved in metabolism, nutrition, pathophysiology, and cell signaling.

Clinical Service Research (CSR)
The Clinical Science Research Core provides training and assistance in clinical research activities including: isotope tracer methods, indirect calorimetry, body composition analysis, mathematical modeling of metabolic kinetics, data analysis, study design and performance, and subject recruitment.